Hydronephrosis

Todayโ€™s path rounds are on ๐ก๐ฒ๐๐ซ๐จ๐ง๐ž๐ฉ๐ก๐ซ๐จ๐ฌ๐ข๐ฌ!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐‡๐ฒ๐๐ซ๐จ๐ง๐ž๐ฉ๐ก๐ซ๐จ๐ฌ๐ข๐ฌ is a cystic enlargement of the kidney due to dilation of the ๐œ๐จ๐ฅ๐ฅ๐ž๐œ๐ญ๐ข๐ง๐  structures, where urine is aggregated prior to making its journey to the bladder. This leads to a kidney that looks a bit like a water balloon!

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
Any species can get this condition!

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
Basically, any form of ๐œ๐จ๐ฅ๐ฅ๐ž๐œ๐ญ๐ข๐ง๐  of the lower urinary tract (ureters, bladder, urethra) can cause this. Urine continues to be made in the kidney, even when the outflow is obstructed, which leads to increased pressure in the urinary system. Eventually, this pressure leads to dilation of the tubular parts of the kidney, causing them to form giant cyst-like structures.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
As the cysts continue to grow, they put pressure on the kidney tissue around them, causing ๐š๐ญ๐ซ๐จ๐ฉ๐ก๐ฒ (cell loss). If both kidneys are affected, or there is some pre-existing disease in the unaffected kidney, the animal may start showing signs of ๐ซ๐ž๐ง๐š๐ฅ ๐Ÿ๐š๐ข๐ฅ๐ฎ๐ซ๐ž. If there is a complete obstruction that prevents all urine outflow, animals will quickly develop signs of ๐ฎ๐ซ๐ž๐ฆ๐ข๐š, the accumulation of toxins normally excreted in the urine.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
Typically the veterinarian will first diagnose the obstruction that caused the hydronephrosis. Signs of urinary obstruction in animals include straining to urinate, small amounts of blood in the urine, or painful urination. From there, they might do an ultrasound of the kidneys, which will quickly reveal a very fluid-filled kidney!

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐?
First and foremost, the obstruction needs to be relieved in order for the animal to have a normal life again. However, the structural changes of hydronephrosis are typically irreversible. In some cases, the veterinarian may elect to remove the affected kidney surgically, after confirming that the remaining kidney has enough function to maintain life.

๐๐ก๐จ๐ญ๐จ๐ฌ
1) A kidney that looks rather like a water balloon.
2-6) Examples of hydronephrosis kidneys after being cut in half, showing all the cysts and compression of the surrounding tissue.

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Maxie, G. Jubb, Kennedy and Palmerโ€™s Pathology of Domestic Animals, Volume 2. Sixth Edition.

Photos 1-6 ยฉ Noahโ€™s Arkive contributor Oโ€™Toole, Jakowski, Niyo, Metro, Mosier licensed under CC BY-SA 4.0.

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