Rickets

Todayโ€™s path rounds are on ๐ซ๐ข๐œ๐ค๐ž๐ญ๐ฌ!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐‘๐ข๐œ๐ค๐ž๐ญ๐ฌ is a disease of the skeleton in growing animals, that results in abnormal formation of bone at the growth plates, as well as poor quality bone in general.

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
Any species can get this! As mentioned previously, this disease specifically affects growing animals prior to the closure of their growth plates.

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
Basically, anything that can interfere with the mineralization of bone can cause rickets, but the majority of cases are due to dietary deficiencies in vitamin D or phosphorous.

Vitamin D deficiency is a major cause of rickets, particularly in animals kept indoors, due to lack of sunlight. Vitamin D plays a major role in calcium regulation by helping with calcium absorption in the diet. So, if an animalโ€™s diet does not contain adequate vitamin D, the calcium levels in the blood stream decline, which stimulates the body to release calcium from the bones. This release of calcium is ultimately the underlying issue in rickets, because the bone cannot mineralize properly as it develops.

Phosphorous is another important factor in the formation of bone, because it is needed to form ๐ก๐ฒ๐๐ซ๐จ๐ฑ๐ฒ๐š๐ฉ๐š๐ญ๐ข๐ญ๐ž, the major mineral in bones. Again, without adequate phosphorous levels, the bone cannot mineralize properly, causing rickets. This typically occurs in animals grazing on pastures where soil levels of phosphorous are low, and the diet is not otherwise balanced.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
Well, having soft bones is not very conducive to living a long, happy and healthy life! These animals are generally very stiff and lame, and may even be reluctant to stand.

The bones often show irregular thickening of the growth plates, which can lead to deformities of the limbs as the growth plates become boney at different rates and thicknesses. This can further lameness and make animals extremely uncomfortable.

The bone itself can also have an irregular and disorganized appearance, reflecting its poor development. Because of how weak the bone structure is, these animals are significantly predisposed to bone fractures, even with mild traumas.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
Typically these lesions are initially diagnosed when the animal fractures a bone seemingly out of the blue. From there, the irregular growth pattern of the bone can be identified on X-ray, because they are less ๐ซ๐š๐๐ข๐จ๐ฉ๐š๐ช๐ฎ๐ž (white) than a normal bone.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐?
Typically, correcting the underlying dietary deficiency is the main treatment for rickets. If the animal is generally kept indoors, then letting it outside for frequently and for longer periods can also help. Usually animals have a good prognosis as long as the growth plates arenโ€™t irreversibly damaged, and bone fractures can be prevented.

๐๐ก๐จ๐ญ๐จ๐ฌ
1-3) Examples of bones displaying an irregular pattern in the ๐ญ๐ซ๐š๐›๐ž๐œ๐ฎ๐ฅ๐š๐ž (main structure) of the bone.
4-5) Two examples where the growth plate (the grey gelatinous looking thing) has also become irregular. Normally they are an even, thin line extending all the way across the bone!
6) A normal bone and growth plate you can use for comparison to the other bones! See how thin the growth plate is?
7) An interesting presentation of rickets often seen in humans and birds called a ๐ซ๐š๐œ๐ก๐ข๐ญ๐ข๐œ ๐ซ๐จ๐ฌ๐š๐ซ๐ฒ. What youโ€™re seeing is enlargement of the ๐œ๐จ๐ฌ๐ญ๐จ๐œ๐ก๐จ๐ง๐๐ซ๐š๐ฅ ๐ฃ๐ฎ๐ง๐œ๐ญ๐ข๐จ๐ง (the cartilage attachment between the ribs and the sternum) due to rickets. Crazy!

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Maxie, G. Jubb, Kennedy and Palmerโ€™s Pathology of Domestic Animals, Volume 1. Sixth Edition.

Photos 2-3, 5-7 courtesy of Noahโ€™s Arkive.
Photos 1 and 4 courtesy of University of Calgary Diagnostic Services Unit.

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