Hypotrichosis with Anodontia

Todayโ€™s path rounds are on ๐ก๐ฒ๐ฉ๐จ๐ญ๐ซ๐ข๐œ๐ก๐จ๐ฌ๐ข๐ฌ ๐ฐ๐ข๐ญ๐ก ๐š๐ง๐จ๐๐จ๐ง๐ญ๐ข๐š!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐‡๐ฒ๐ฉ๐จ๐ญ๐ซ๐ข๐œ๐ก๐จ๐ฌ๐ข๐ฌ ๐ฐ๐ข๐ญ๐ก ๐š๐ง๐จ๐๐จ๐ง๐ญ๐ข๐š is a pretty complex name, so lets break it down. ๐‡๐ฒ๐ฉ๐จ๐ญ๐ซ๐ข๐œ๐ก๐จ๐ฌ๐ข๐ฌ means poor development of the hair follicles (hypo- meaning less, and trich- meaning hair), while ๐š๐ง๐จ๐๐จ๐ง๐ญ๐ข๐š means lack of teeth (an- meaning not, and odont- meaning teeth). So these animals have no teeth and minimal hair!

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
While this condition can be seen in many species, we most commonly think of it in cattle.

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
In cattle, this disease is ๐ข๐ง๐ก๐ž๐ซ๐ข๐ญ๐ž๐ through the ๐— ๐ ๐ž๐ง๐ž. Female animals have two X genes in their cells, while males have one X and one Y. Because this condition is ๐ซ๐ž๐œ๐ž๐ฌ๐ฌ๐ข๐ฏ๐ž, meaning it only expresses itself if it is the only gene present, male animals more susceptible to the condition. In females, the second X with the โ€œcorrectโ€ gene may override the affected gene, producing a normal animal. So for a female to be affected, both X genes would have to have the affected gene. Males do not have the benefit of a second X gene in their cells, making them more susceptible.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
This condition affects the development of the ๐ž๐œ๐ญ๐จ๐๐ž๐ซ๐ฆ, one of the layers of the embryo, preventing the normal structures that develop from the ectoderm from forming in the developing fetus. This includes the hair follicles, skin glands and teeth! So, these animals are often poorly haired, and have little to no tooth development. Typically horned animals will also not develop their horns.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
This is pretty easy to diagnose, just by looking at the animal!

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐?
Unfortunately, there is no treatment for these animals. Because the lack of teeth makes it difficult for them to lead a normal bovine life, these calves are often euthanized.

๐๐ก๐จ๐ญ๐จ๐ฌ
1-4) Examples of hairless calves!
5) The mouth of a calf with anodontia, showing little to no tooth development.

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Zachary JF. Pathologic Basis of Veterinary Disease. Sixth Edition.

Photos 1-5 ยฉ Noahโ€™s Arkive contributors Harrington, Nation, Leipold, Oโ€™toole, Mosier licensed under CC BY-SA 4.0.

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