Sarcoids

Todayโ€™s path rounds are on ๐ž๐ช๐ฎ๐ข๐ง๐ž ๐ฌ๐š๐ซ๐œ๐จ๐ข๐๐ฌ!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐’๐š๐ซ๐œ๐จ๐ข๐๐ฌ are the most commonly diagnosed tumour of horses! They occur in the skin, and generally are pretty harmless. There are 6 recognized types, ranging from a hairless patch of skin to large, aggressive masses.

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
Any age, breed or sex of horse can get these!

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
Interestingly, these masses are believed to be caused by ๐›๐จ๐ฏ๐ข๐ง๐ž ๐ฉ๐š๐ฉ๐ข๐ฅ๐ฅ๐จ๐ฆ๐š๐ฏ๐ข๐ซ๐ฎ๐ฌ! Yes, you read that right, a cow virus causing a tumour in horses. Wild! There is a lot of evidence to suggest that the virus is spread to horses by flies landing on scrapes, cuts or other wounds, thus introducing the virus into the horseโ€™s system.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
As mentioned, these tumours generally donโ€™t cause an issue as they are considered relatively benign. It is also extremely rare for them to ๐ฆ๐ž๐ญ๐š๐ฌ๐ญ๐š๐ฌ๐ข๐ณ๐ž (spread to distant sites), unlike some other tumour types. However, sometimes they can become quite large and ๐ฎ๐ฅ๐œ๐ž๐ซ๐š๐ญ๐ž๐ (bleeding from the surface), and potentially interfere with the horseโ€™s day-to-day activities.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
Often these tumours are diagnosed just by looking at them. Normally, a ๐›๐ข๐จ๐ฉ๐ฌ๐ฒ (looking at tissue under a microscope) would be the best method of diagnosis, similar to other tumours. However, these tumours are known to become more aggressive after being disturbed, often expanding in size uncontrollably after being damaged. So often veterinarians are quite cautious about angering these tumours, even though they are technically benign.

If a biopsy is done, the biopsy will show long extensions of the ๐ž๐ฉ๐ข๐๐ž๐ซ๐ฆ๐ข๐ฌ (outer layer of the skin) down into the deeper layers of the skin. Super neat!

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐?
If the sarcoid is in a location that does not bother the horse, sometimes these tumours are โ€œtreatedโ€ with ๐›๐ž๐ง๐ข๐ ๐ง ๐ง๐ž๐ ๐ฅ๐ž๐œ๐ญ, otherwise known as doing nothing. However, if they are bothering the horse, or the owner, there are a variety of treatments that can be tried.

Surgical excision is the most obvious one, where the tumour is simply removed. However, there have also been promising results with ๐œ๐ซ๐ฒ๐จ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ (freezing the tumour with liquid nitrogen), antiviral drugs to kill the virus, or even local ๐œ๐ก๐ž๐ฆ๐จ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ (applying chemicals that kill cells). It is important to note that treated sarcoids tend to come back, and may even be more aggressive upon their return! So a discussion with your veterinarian regarding the pros and cons of treatment is key.

๐๐ก๐จ๐ญ๐จ๐ฌ
1-7) Various types of sarcoids in different locations. See how they can range from flat, hairless areas to huge masses?
8 ) An example of what a pathologist would see under a microscope! Those long bright pink strands extending into the tissue are a hallmark sign of sarcoids.

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Villalobos, AE. Equine sarcoids. Merck Veterinary Manual, 2014.

Photos 2-8 ยฉ Noahโ€™s Arkive contributors Giles, Jakowski, Wright, Eastep, Ward, Wallace licensed under CC BY-SA 4.0.

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