Equine Infectious Anemia

Todayโ€™s path rounds are on ๐ž๐ช๐ฎ๐ข๐ง๐ž ๐ข๐ง๐Ÿ๐ž๐œ๐ญ๐ข๐จ๐ฎ๐ฌ ๐š๐ง๐ž๐ฆ๐ข๐š!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐„๐ช๐ฎ๐ข๐ง๐ž ๐ข๐ง๐Ÿ๐ž๐œ๐ญ๐ข๐จ๐ฎ๐ฌ ๐š๐ง๐ž๐ฆ๐ข๐š is a viral disease caused by a ๐ซ๐ž๐ญ๐ซ๐จ๐ฏ๐ข๐ซ๐ฎ๐ฌ. This disease is highly transmissible with no known treatment, and infected horses will carry the virus for the rest of their lives. Therefore, prevention of this disease is critical!

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
Any horse can get this disease!

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
As mentioned, this disease is caused by a retrovirus. An infected horse is not directly contagious to other horses under most circumstances, meaning it cannot spread the disease on its own. So, the virus uses blood-sucking insects to hitch a ride between hosts! When a biting fly or mosquito feeds on the infected horse, the virus contaminates its mouthparts, allowing it to enter another horse during the insectโ€™s next feeding. Another way the virus can transfer to another horse is re-use of bloody medical equipment like needles, surgical instruments or dental tools.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
The virus primarily infects ๐ฆ๐š๐œ๐ซ๐จ๐ฉ๐ก๐š๐ ๐ž๐ฌ, which are the bodyโ€™s main clean-up cell. This infection results in a widespread immune response to try and clear the invader. However, this immune response has consequences for the animalโ€™s blood cells, primarily their ๐ฉ๐ฅ๐š๐ญ๐ž๐ฅ๐ž๐ญ๐ฌ (clotting cells) and red blood cells. The immune system overreacts to them, causing their destruction. This leads to ๐ญ๐ก๐ซ๐จ๐ฆ๐›๐จ๐œ๐ฒ๐ญ๐จ๐ฉ๐ž๐ง๐ข๐š (low platelets) and ๐š๐ง๐ž๐ฆ๐ข๐š (low red blood cells). Horses experiencing these problems may spontaneously bleed due to their lack of platelets, and are extremely lethargic with an increased heart and respiratory rate as their body tries to compensate for the reduced oxygen capacity of the blood. In some cases, the immune system may also attack the blood vessel wall, causing leakage of fluid into the tissues. This results in ๐ž๐๐ž๐ฆ๐š.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
EIA is diagnosed using ๐ฌ๐ž๐ซ๐จ๐ฅ๐จ๐ ๐ข๐œ ๐ญ๐ž๐ฌ๐ญ๐ฌ, meaning a sample of blood from the horse is exposed to the virus. If there are antibodies against the virus in the blood, the horse may be considered positive. Other supplemental tests will then be used to confirm whether the horse is truly infected.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐?
As mentioned, there is no treatment for this disease, so prevention is key! Unfortunately, horses that test positive are a significant risk to their peers, so most governments mandate their euthanasia to prevent further spread of the disease. However, there are now some sanctuaries for infected horses available where they are kept at a great distance from any non-infected horse, allowing them to live out the rest of their days.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ฉ๐ซ๐ž๐ฏ๐ž๐ง๐ญ๐ž๐?
The mainstay of EIA prevention is the ๐‚๐จ๐ ๐ ๐ข๐ง๐ฌ ๐ญ๐ž๐ฌ๐ญ, the same serologic test used to identify positive animals. Any horses interacting with or mixing with other horses at shows, events, etc should be tested and confirmed negative. Disinfection of surgical equipment, using needles a single time only and diligent insect control are also important in preventing this disease.

๐๐ก๐จ๐ญ๐จ๐ฌ
1-4) A poor horse with EIA, demonstrating widespread edema. Edema in horses tends to accumulate on their ๐ฏ๐ž๐ง๐ญ๐ซ๐š๐ฅ surface (stomach-side), as you can see in this horse. His ๐œ๐จ๐ง๐ฃ๐ฎ๐ง๐œ๐ญ๐ข๐ฏ๐š (membrane around the eye) is also extremely pale due to his anemia.

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Timoney PJ. Equine Infectious Anemia. Merck Veterinary Manual 2020.

Photos 1-4 ยฉย Wikimedia Commons contributor Darreenvt licensed under CC Share-Alike 4.0 International.

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