Chlamydiosis

Todayโ€™s path rounds are on ๐œ๐ก๐ฅ๐š๐ฆ๐ฒ๐๐ข๐จ๐ฌ๐ข๐ฌ!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐‚๐ก๐ฅ๐š๐ฆ๐ฒ๐๐ข๐จ๐ฌ๐ข๐ฌ is infection with ๐‚๐ก๐ฅ๐š๐ฆ๐ฒ๐๐ข๐š, a species of bacteria. Youโ€™ve probably heard of Chlamydia in people!

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
While Chlamydia affects many species, today weโ€™re going to talk about Chlamydia in koalas. Chlamydiosis is actually the most common infectious disease of koalas, and has a significant impact on the survival of the species.

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
Most cases of chlamydiosis in koalas are caused by ๐‚๐ก๐ฅ๐š๐ฆ๐ฒ๐๐ข๐š ๐ฉ๐ž๐œ๐จ๐ซ๐ฎ๐ฆ, which is present in almost all free-ranging koala populations. In fact, some studies have shown that some groups of koalas have up to 100% of the population infected! Thankfully, not all koalas infected with the bacteria will show symptoms. This bacteria, similar to the human bacteria, is ๐ฌ๐ž๐ฑ๐ฎ๐š๐ฅ๐ฅ๐ฒ ๐ญ๐ซ๐š๐ง๐ฌ๐ฆ๐ข๐ญ๐ญ๐ž๐, but can also be passed to young koalas during birth or through the milk of the mother.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
Chlamydia likes to live within cells, causing the immune system to target those cells for destruction to try and control the infection. This can lead to tissue damage. In particular, Chlamydia targets the ๐ฎ๐ซ๐จ๐ ๐ž๐ง๐ข๐ญ๐š๐ฅ ๐ญ๐ซ๐š๐œ๐ญ and the ๐œ๐จ๐ง๐ฃ๐ฎ๐ง๐œ๐ญ๐ข๐ฏ๐š (mucosa around the eye). Female koalas can develop ๐ฉ๐ฒ๐จ๐ฆ๐ž๐ญ๐ซ๐š (pus in the uterus), ๐ฆ๐ž๐ญ๐ซ๐ข๐ญ๐ข๐ฌ (infection of the uterus wall) and other infections. Male koalas can get infections of the testicles and prostate. These infections can be fatal in some cases. The conjunctiva typically shows redness and swelling, called ๐œ๐จ๐ง๐ฃ๐ฎ๐ง๐œ๐ญ๐ข๐ฏ๐ข๐ญ๐ข๐ฌ.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
Typically the findings of conjunctivitis or urogenital infection are sufficient to diagnose the bacteria in koalas. However, if the veterinarian wants to confirm the diagnosis, they can do ๐๐‚๐‘ to detect the bacterial DNA directly.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐? ๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ฉ๐ซ๐ž๐ฏ๐ž๐ง๐ญ๐ž๐?
Typically koalas are treated with antibiotics, particularly ๐๐จ๐ฑ๐ฒ๐œ๐ฒ๐œ๐ฅ๐ข๐ง๐ž. There is also a Chlamydia vaccine that has just entered the trial stage, designed to help reduce the severity of infection and allow the koala a better chance of survival.

๐๐ก๐จ๐ญ๐จ๐ฌ
1-3) Examples of koalas with conjunctivitis from Chlamydia.
4) The uterus of a koala with pyometra, showing the severe expansion of the uterus with pus.
5) Little blue dit-dots of Chlamydia within some cells scraped off the conjunctiva.

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Terio, KA, McAloose, D, St. Leger, J. Pathology of Wildlife and Zoo Animals. 2018.

Photos 1-5 ยฉ Noahโ€™s Arkive contributors King, Rebar licensed under CC BY-SA 4.0.

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