Avian Flu

Todayโ€™s path rounds are on ๐š๐ฏ๐ข๐š๐ง ๐Ÿ๐ฅ๐ฎ!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐€๐ฏ๐ข๐š๐ง ๐Ÿ๐ฅ๐ฎ, or avian influenza, is a viral infection that affects many different bird species. Recently, there have been outbreaks of the strain ๐‡๐Ÿ“๐๐Ÿ across the world, which has been devastating for poultry production and wildlife species.

๐–๐ก๐š๐ญ ๐š๐ซ๐ž ๐ญ๐ก๐ž๐ฌ๐ž ๐‡๐ฌ ๐š๐ง๐ ๐๐ฌ?
Whenever there is a new strain of influenza out there, you will often here it referred to as H_N_, with different numbers in the blanks. This is referring to the two main ๐ฏ๐ข๐ซ๐ฎ๐ฅ๐ž๐ง๐œ๐ž ๐Ÿ๐š๐œ๐ญ๐จ๐ซ๐ฌ, or factors that allow spread of the disease, that influenza has. These factors are called ๐ก๐ž๐ฆ๐š๐ ๐ ๐ฅ๐ฎ๐ญ๐ข๐ง๐ข๐ง (hence the H) and ๐ง๐ž๐ฎ๐ซ๐š๐ฆ๐ข๐ง๐ข๐๐š๐ฌ๐ž (hence the N). The number refers to the particular variant of these two virulence factors that viral strain has. Strains with hemagglutinin 5 and 7 are considered to be ๐ก๐ข๐ ๐ก๐ฅ๐ฒ ๐ฉ๐š๐ญ๐ก๐จ๐ ๐ž๐ง๐ข๐œ, or very very bad viruses!

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
Avian influenza can affect pretty much any bird species, including wild populations. Some strains can also infect humans!

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
As mentioned, this disease is caused by an influenza virus, which is transmitted between birds by ingesting contaminated material or inhaling the virus. The virus is also incredibly โ€œstickyโ€, meaning it can attach itself to surfaces like shoes, clothing, or vehicles, allowing spread to distant farms. Once a bird is infected, it can take up to 2 weeks before the bird develops clinical signs that indicate infection.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
The highly pathogenic strains of avian influenza have an extremely high ๐ฆ๐จ๐ซ๐ญ๐š๐ฅ๐ข๐ญ๐ฒ (death rate) in chickens and turkeys, which can approach 100% of infected birds in some cases. One of the main cell types that the virus infects is ๐ž๐ง๐๐จ๐ญ๐ก๐ž๐ฅ๐ข๐ฎ๐ฆ, the cells lining blood vessels. This can cause hemorrhage, ๐ž๐๐ž๐ฆ๐š (leaking of fluid into tissue) and ๐ญ๐ก๐ซ๐จ๐ฆ๐›๐จ๐ฌ๐ข๐ฌ (blood clots in a vessel preventing flow). Ultimately, this disrupted blood flow is what causes death in these poor birds.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
To confirm the presence of the virus, swabs can be taken of the mouth or ๐œ๐ฅ๐จ๐š๐œ๐š (combined urinary, reproductive and gastrointestinal opening in birds) to detect the virusโ€™ ๐‘๐๐€ (kinda like DNA). The virus can also be cultured from these swabs to confirm the diagnosis.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐? ๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ฉ๐ซ๐ž๐ฏ๐ž๐ง๐ญ๐ž๐?
Unfortunately, the high mortality rate of this disease makes treatment impractical in many situations. Therefore, prevention is key! Extensive biosecurity measures are needed to keep this โ€œstickyโ€ virus off of farms, including thorough cleaning of all objects (including humans!) moving between properties with birds on them. There are also some vaccines available, however they have to be specifically matched to the influenza strain.

๐๐ก๐จ๐ญ๐จ๐ฌ
1) A chicken with ๐œ๐ฒ๐š๐ง๐จ๐ฌ๐ข๐ฌ (blue discoloration of the tissue) due to difficulty breathing.
2) An example of why cyanosis might occur! This photo shows froth and fluid accumulating in the ๐š๐ข๐ซ ๐ฌ๐š๐œ๐ฌ of a turkey, which are part of the respiratory system of birds.
3-4) Hemorrhage on the legs and ๐ข๐ง๐Ÿ๐š๐ซ๐œ๐ญ๐ฌ (dead tissue caused by thrombosis) on the comb and wattles of chickens. These are pretty classic signs of avian influenza!

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Swayne DE. Avian influenza. Merck Veterinary Manual 2021.

Photos 1-4 ยฉ Noahโ€™s Arkive contributors Williams, Jakowski licensed under CC BY-SA 4.0.

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