Uterine Adenocarcinoma

Todayโ€™s path rounds are on ๐ฎ๐ญ๐ž๐ซ๐ข๐ง๐ž ๐š๐๐ž๐ง๐จ๐œ๐š๐ซ๐œ๐ข๐ง๐จ๐ฆ๐š!

๐–๐ก๐š๐ญ ๐ข๐ฌ ๐ข๐ญ?
๐”๐ญ๐ž๐ซ๐ข๐ง๐ž ๐š๐๐ž๐ง๐จ๐œ๐š๐ซ๐œ๐ข๐ง๐จ๐ฆ๐š๐ฌ are tumours of the uterine lining. The risk of these tumours increases with the age of the animal, and they are particularly common in rabbits!

๐–๐ก๐จ ๐ ๐ž๐ญ๐ฌ ๐ข๐ญ?
As mentioned, this condition is most commonly seen in rabbits. In fact, it is the most common tumour of female rabbits. More than 50% of rabbits over 3 years of age will have this tumour!

๐–๐ก๐š๐ญ ๐œ๐š๐ฎ๐ฌ๐ž๐ฌ ๐ข๐ญ?
Like many cancers, the exact cause is unknown. However, it is thought that high levels of ๐ž๐ฌ๐ญ๐ซ๐จ๐ ๐ž๐ง, the major hormone in non-pregnant animals, may contribute to development of this tumour.

๐–๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐š ๐ฉ๐ซ๐จ๐›๐ฅ๐ž๐ฆ?
These tumours are particularly aggressive, and often ๐ฆ๐ž๐ญ๐š๐ฌ๐ญ๐š๐ฌ๐ข๐ณ๐ž (spread) to other organs. In particular, it likes to spread to the lugs, liver and ๐ฉ๐ž๐ซ๐ข๐ญ๐จ๐ง๐ž๐ฎ๐ฆ (lining surfaces of the abdomen). They can also interfere with the rabbitโ€™s ability to become pregnant and maintain a pregnancy.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐๐ข๐š๐ ๐ง๐จ๐ฌ๐ž๐?
Often, the tumour can be felt when palpating the rabbitโ€™s abdomen. The mass or masses can often be seen on X-rays and ultrasound as well.

๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ญ๐ซ๐ž๐š๐ญ๐ž๐? ๐‡๐จ๐ฐ ๐ข๐ฌ ๐ข๐ญ ๐ฉ๐ซ๐ž๐ฏ๐ž๐ง๐ญ๐ž๐?
Treatment is often difficult, due to the aggressive behaviour of these tumours. Often, by the time the tumour is detected, the tumour has already spread. If caught early, ๐จ๐ฏ๐š๐ซ๐ข๐จ๐ก๐ฒ๐ฌ๐ญ๐ž๐ซ๐ž๐œ๐ญ๐จ๐ฆ๐ฒ (โ€œspayโ€) is the treatment of choice. Similarly, the best method of prevention is spaying any female rabbits that will not be used for breeding.

๐๐ก๐จ๐ญ๐จ๐ฌ
1-4) Lumpy uteruses with uterine adenocarcinoma!
5) What a section of these uteruses might look like. Normally, you should see an empty ๐ฅ๐ฎ๐ฆ๐ž๐ง (central space), but in this case the lumen is compressed by the tumour.

๐’๐จ๐ฎ๐ซ๐œ๐ž๐ฌ
Terio, KA, McAloose, D, St. Leger, J. Pathology of Wildlife and Zoo Animals. 2018.

Photos 1-5 ยฉ Noahโ€™s Arkive contributors Hoenerhoff, Reyes-Gomez, Jennings, King, licensed under CC BY-SA 4.0.

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